| The Trust For Public LandAppalachian Regional Commission | Grant | $10,000,000 | — | ARTS-CULTURE-TOURISM | |
| American Association Of Community CollegesAppalachian Regional Commission | Grant | $10,000,000 | — | WORKFORCE TRAINING | |
| Fletcher Group INCAppalachian Regional Commission | Grant | $9,228,218 | — | WORKFORCE TRAINING | |
| Yellow Creek State Inland Port AuthorityAppalachian Regional Commission | Grant | $9,000,000 | — | SECTOR-BASED STRATEGIES | |
| Mountain State EscAppalachian Regional Commission | Grant | $7,030,989 | — | EDUCATIONAL ACHIEVEMENT/ATTAINMENT | |
| Rural Health Redesign Center Organization, INC.Appalachian Regional Commission | Grant | $5,200,000 | — | WORKFORCE TRAINING | |
| Blue Ridge Parkway FoundationAppalachian Regional Commission | Grant | $5,130,000 | — | ARTS-CULTURE-TOURISM | |
| Morehead State UniversityAppalachian Regional Commission | Grant | $3,980,996 | — | CAREER & TECHNICAL EDUCATION | |
| Backroads Of Appalachia, INC.Appalachian Regional Commission | Grant | $3,809,250 | KY | ARTS-CULTURE-TOURISM | |
| Mountain Bizcapital INCAppalachian Regional Commission | Grant | $3,500,000 | NC | ACCESS TO CAPITAL | |
| Mcdowell County PsdAppalachian Regional Commission | Grant | $3,499,000 | WV | COMMUNITY INFRASTRUCTURE | |
| Athens, County OfAppalachian Regional Commission | Grant | $3,444,000 | OH | COMMUNITY INFRASTRUCTURE | |
| Backroads Of Appalachia, INC.Appalachian Regional Commission | Grant | $3,360,000 | WV | ARTS-CULTURE-TOURISM | |
| Clay, County OfAppalachian Regional Commission | Grant | $3,303,730 | WV | COMMUNITY INFRASTRUCTURE | |
| Lee County VaAppalachian Regional Commission | Grant | $3,200,000 | VA | COMMUNITY INFRASTRUCTURE | |
| Mingo County PsdAppalachian Regional Commission | Grant | $3,000,000 | WV | COMMUNITY INFRASTRUCTURE | |
| Region I Planning & Development CouncilAppalachian Regional Commission | Grant | $2,989,361 | WV | RESEARCH & EVALUATION | |
| Thrive Regional Partnership, INCAppalachian Regional Commission | Grant | $2,870,702 | — | SECTOR-BASED STRATEGIES | |
| Ravencliff Mcgraws SaulsvilleAppalachian Regional Commission | Grant | $2,700,000 | WV | COMMUNITY INFRASTRUCTURE | |
| City Of WinchesterAppalachian Regional Commission | Grant | $2,700,000 | KY | COMMUNITY INFRASTRUCTURE | |
| City Of BeattyvilleAppalachian Regional Commission | Grant | $2,500,000 | KY | COMMUNITY INFRASTRUCTURE | |
| Mt. Zion Public Service DistrictAppalachian Regional Commission | Grant | $2,350,000 | WV | COMMUNITY INFRASTRUCTURE | |
| U.S. Space & Rocket Center Education FoundationAppalachian Regional Commission | Grant | $2,350,000 | AL | EDUCATIONAL ACHIEVEMENT/ATTAINMENT | |
| City Of HazardAppalachian Regional Commission | Grant | $2,206,320 | KY | COMMUNITY INFRASTRUCTURE | |
| Bartow County TreasurerAppalachian Regional Commission | Grant | $2,000,000 | GA | COMMUNITY INFRASTRUCTURE | |